Kidney, Papilla – Necrosis

Figure Legend: Figure 1 Kidney, Papilla Necrosis in a male F344/N rat from a chronic study. Early necrosis of the papilla shows loss of cellular detail and staining affinity. Figure 2 Kidney, Papilla Necrosis in a male F344/N rat from a subchronic study. A portion of the necrotic renal papilla is sloughed off into the renal pelvis. Figure 3 Kidney, Papilla Necrosis in a female B6C3F1 mouse from a chronic study. There is a large area of papillary necrosis with a prominent peripheral zone of inflammation. Figure 4 Kidney, Papilla Necrosis in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3). Acute necrosis and inflammatory infiltrate are present.